House Full revolves around two irresponsible friends Diganth and Parameshi who dream of a big debut in the film industry. Parameshi is a parasite who lives off Diganth's riches. He is married to Neetu, an aspiring star in the making, and Diganth is in love with a girl named Aishu. Diganth's grandfather is in South Africa and wants his grandson reformed. Diganth lies to his grandfather that he is married to Aishu. Confusion is created by Diganth's deputy Pani Puri, who mails Neetu's photo to the grandfather instead of Aishu's photo. And then the whole confusion starts with each of the four characters placed in many strange situations.